Indications:
- Myelodysplastic Syndromes (MDS):
- Refractory anemia or anemia with excess blasts.
- Chronic myelomonocytic leukemia (CMML).
- Intermediate-2 and high-risk MDS based on the International Prognostic Scoring System (IPSS).
- Acute Myeloid Leukemia (AML):
- For patients with AML who are not candidates for intensive chemotherapy.
Azadual incorporates into DNA and RNA, inhibiting DNA methyltransferase. This results in hypomethylation of DNA and reactivation of silenced tumor suppressor genes. The drug also disrupts RNA processing, which may contribute to its anti-cancer effects. These mechanisms slow or stop the growth of abnormal cells and promote normal cell development.
